Mathieu replied: "100 mg of Wellbutrin is not a lot, it is the lowest therapeutic dose average doses are 150-300 mg and 400 mg is the maximum dose. The amount of Risperdal you are on is a large dose. The maximum is 4 mg but you are certainly on a large dose. What are you being treated for? Bipolar, depression, schizophrenia? They are certainly a safe mixture, it would be usual for a doctor to prescribe drugs with dangerous interactions. The only possible interaction is that they can increase the risk of seizures (both can increase the risk on their own too) so if you had epilepsy then your doctor would be very cautious with medications. When you say you have been sober for months does than mean you have a substance abuse problem or you just have not taken it for months? Yeah there will absolutely be interactions. What they would be exactly I can't say because everyone is different and it is an uncommon mix of drugs. One way to think about it is that you would be on three psychotropic drugs- would you feel safe mixing marijuana, LSD, and methamphetamine? The answer is that would be a terrible idea. And although Wellbutrin and Risperdal are prescribed they are still psychotropic and without supervised use there are risks, especially due to the highly complicated natures of Wellbutrin and Risperdal. And if you did smoke marijuana you could get worse, you could really interfere with the medications. If you do smoke or are going to smoke tell your doctor (if he dose not know). He won't call the police, he won't tell your family without your connect. I won't lecture you on the "evils" of drugs because it is stupid to lecture but it can cause problems, especially if your doctor does not know. If you have been manic or had a psychotic episode marijuana will just cause problems. Good luck"